All products featured on Vogue are independently selected by our editors. However, we may receive compensation from retailers and/or from purchases of products through these links.
When it comes to shopping for topical products that keep fine lines and creases at bay, it’s important to keep expectations, shall we say, realistic. Though the best wrinkle fillers can keep the skin hydrated and pump between wrinkle-reducing procedures performed in-clinic, they are not replacements for injectables. However, they can work in tandem with Botox and fillers—and they also deliver smoothing benefits on their own, even for those who shudder at the thought of a needle.
Vogue’s Favorite Wrinkle Fillers:
- Best Drugstore: RoC Derm Correxion Fill + Treat Serum, $30
- Best Peptide Serum: SkinCeuticals P-Tiox, $148
- Best Wrinkle Patch: 111Skin Wrinkle Erasing Retinol Patches, $190
- Best Hyaluronic Acid Serum: Alastin Skincare HA Immerse Serum, $127
- Best for Growth Factors: SkinMedica TNS Advanced+ Serum, $295
- Best Ultra-Luxe: La Prairie Platinum Rare Haute-Rejuvenation Mask, $1,775
- Best for Refining Pores: DRMTLGY Needle-less Serum, $69
- Best for Under-Eye Wrinkles: Revision Skincare Revox Line Relaxer, $184
- Best Retinol Alternative: L’Oréal Paris Collagen Moisture Filler, $19
Kenneth Mark, FAAD, FACMS, a board-certified cosmetic dermatologist and injectables expert, likes to level the field for his patients before recommending the best wrinkle fillers to use at home. “Botox inhibits muscle movement to decrease wrinkles, while filler technology has evolved to produce dramatic, long-lasting, volume-enhancing, lifting and rejuvenating effects,” he says. “These results cannot be produced at home. The technology for fillers has evolved, and they no longer are just ‘fillers’ for lines, wrinkles, and lips as was the case 25 years ago. Now, we can literally add structure and definition and reshape and lift and contour the face. You will not accomplish this with topical wrinkle fillers.”
However, there are many things the best wrinkle fillers can accomplish, and Dr. Mark and other pros are quick to recommend the best of them—which range from super-luxe, groundbreaking creams to drugstore standbys—to patients.
Ahead, find the best wrinkle fillers to flood the skin with hydration, boost collagen production, and deliver other benefits that can allay the return of wrinkles between appointments.
In This Story:
- Do wrinkle fillers really work?
- Which wrinkle filler is best?
- What ingredients should you look for in a wrinkle filler?
- Can similar results to Botox and filler be achieved at home?
- How long do wrinkle fillers last?
- Meet the experts
Best Drugstore: RoC Derm Correxion Fill + Treat Serum
- Why We Love It: When Vogue’s senior beauty shopping writer Kiana Murden asked her board-certified aesthetic injector, Akis Ntonis, for his top wrinkle-filler picks, RoC’s drugstore gem quickly came to mind. Designed to target frown lines, crow’s feet, and laugh lines, “This serum utilizes hyaluronic acid to hydrate and fill in wrinkles, making the skin look smoother and more youthful,” Ntonis says. Created with input from dermatologists and plastic surgeons, the serum also harnesses retinol to smooth fine lines. Another key ingredient, swertiamarin, is a plant-based compound that thickens the surface of the skin to reduce the appearance of fine lines and wrinkles. The brand recommends applying the serum directly to wrinkles, morning and night.
- Key Ingredients: Retinol, hyaluronic acid, swertiamarin
- Fragrance-Free: Yes
- Size: 0.34 ounces
Best Peptide Serum: SkinCeuticals P-Tiox
- Why We Love It: Promising to deliver a glass-skin glow and target nine kinds of expression lines in just one week, SkinCeuticals’s claims for its wrinkle-modulating peptide serum intrigued Vogue contributor Deanna Pai. “At 34, I’m a prime candidate for regular neuromodulator appointments and microneedling treatments, so anything that promises to replicate the results of botulinum toxin—which works by inhibiting the neurotransmitters that activate certain facial muscles, thus keeping them relaxed—is a no-brainer for me,” Pai said. After testing the serum for a week, Pai reported that her skin was, indeed, glassier (or at least smoother) than before. “What was impressive, however, was the more immediate change in my skin texture,” she said. “I have oily skin with breakouts and dark spots that often follow, and saw that my typically large pores [and hyperpigmentation] looked less noticeable after just several days of using the serum.” Of note: The brand recommends using the product for at least 12 weeks to see the maximum effects.
- Key Ingredients: Patent-pending peptide blend, PHA, niacinamide, laminaria extract
- Fragrance-Free: Yes
- Size: 1 ounce
Best Retinol Alternative: L’Oréal Paris Collagen Moisture Filler
- Why We Love It: Though Dr. Mark advocates using retinol to fill wrinkles, he admits that not all skin types can tolerate vitamin A derivative, which causes sensitivity in some. Enter this best-kept secret from the drugstore aisle. “L’Oréal Collagen Moisture Filler is great for those averse or sensitive to using retinol,” Dr. Mark says. “This product relies on its rich, moisturizing base of shea butter and collagen itself [to fill wrinkles] instead of using retinol.” He’s witnessed the cream’s results in his own smooth-skinned clientele, who show up for their injections buzzing about the product. “Patients notice an improved appearance of wrinkles fast, in days to weeks, instead of relying on the more physiological, retinoid-induced collagen production that pans out over time,” he says.
- Key Ingredients: Shea butter, collagen
- Fragrance-Free: Fragranced and fragrance-free options are available
- Size: 3.4 ounces
Best for Growth Factors: SkinMedica TNS Advanced+ Serum
- Why We Love It: SkinMedica’s lightweight serum is a go-to for Saami Khalifian, MD, FAAD, a board-certified dermatologist at SOM Aesthetics in Encinitas, California. “This is a gold standard in my clinic,” he says. “It uses a proprietary blend of growth factors and peptides to support collagen and visibly reduce wrinkles and texture over time.” Also infused with marine extract and green microalgae to enhance the results of the growth factor blend, “the serum is great post-procedure and for long-term skin health,” Dr. Khalifian says. Speaking of gold standards, he adds that peptides are one of the best ingredients for firming the skin and boosting collagen production.
- Key Ingredients: Growth factors, peptides, marine extract, green microalgae
- Fragrance-Free: Yes
- Size: 1 ounce
Best Serum: Shiseido Bio-Performance Skin Filler Serum Duo
- Why We Love It: Shiseido’s two-serum set comes with one for daytime use and a counterpart for nighttime; both are designed to fill and expand the skin for a smoother, bouncier look. “This focuses on revitalizing the skin’s natural ability to regenerate, using advanced technology to reduce wrinkles and improve skin density,” Dr. Ntonis says. By day, the Full Expansion Serum harnesses molecule-reshaping technology to create a moisture-retaining layer that gives the skin a more lifted look. Stepping in for the night shift, the Infil Serum sends hyaluronic acid molecules deep into the skin for firming effects.
- Key Ingredients: Hyaluronic acid
- Fragrance-Free: No
- Size: 1 ounce per serum
Best Wrinkle Patch: 111Skin Wrinkle Erasing Retinol Patches
- Why We Love It: “These patches deliver concentrated retinol directly to targeted areas, promoting cell renewal and reducing the appearance of wrinkles,” Dr. Ntonis notes. In shapes designed to cover expression lines, frown lines, crow’s feet, and nasolabial folds, the patches have been clinically proven to reduce the appearance of wrinkles between the brows. Even better, the overnight treatment works while you sleep. Nicole Ruth, DO, FAAD, a board-certified dermatologist in New York City, is also a fan: “[Featuring] hyaluronic acid, vitamin C, retinol, and polypeptides, these wrinkle patches deliver hydration and plumping effects to reduce fine lines,” she previously told Vogue. “These luxury patches are crafted to provide a spa-like experience with visible, short-term smoothing results.”
- Key Ingredients: Retinol, vitamin C, polypeptides
- Fragrance-Free: Yes
- Size: 3 treatments per package
Best for Frown Lines: Dr. Dennis Gross Skincare DermInfusions Fill + Repair Serum
- Why We Love It: Made with four weights of hyaluronic acid to target different layers of the skin, Dr. Dennis Gross’s cushiony serum was designed to fill in fine lines while plumping and firming the complexion. Packed with potent antioxidants, including niacinamide and ectoin, the gel-textured serum “aims to repair skin damage while plumping and hydrating the skin,” Dr. Ntonis explains. What’s more, the treatment is proven to deliver swift results. In clinical tests, the serum filled the look of fine lines after two weeks and reduced redness after four.
- Key Ingredients: Hyaluronic acid, niacinamide, peptide proteins
- Fragrance-Free: No
- Size: 1 ounce
Best for Refining Pores: DRMTLGY Needle-less Serum
- Why We Love It: “Known for its peptide-rich formula, this serum aims to mimic the effects of professional treatments by deeply penetrating the skin to reduce the appearance of lines and wrinkles,” Dr. Ntonis says. Infused with hyaluronic acid—a mainstay in wrinkle-filling—the serum also has niacinamide, which refines the pores while strengthening the skin barrier. At the heart of the formula, the brand’s patented Cerapep Technology uses a blend of peptides and ceramides to reinforce the skin’s natural moisture barrier and give the complexion a fuller, firmer look. The brand recommends using four to five drops of the serum on slightly damp skin morning and night; in clinical studies, results started to show after some 60 days.
- Key Ingredients: hyaluronic acid, niacinamide, Cerapep Technology (peptides and ceramides)
- Fragrance-Free: Yes
- Size: 1 ounce
Best for Under-Eye Wrinkles: Revision Skincare Revox Line Relaxer
- Why We Love It: Designed to optimize the effects of a neuromodulator, Revision’s line-relaxing formula also benefits those who’ve never gone under the needle. “This utilizes a blend of peptides and botanical extracts to target expression lines, offering a smoother complexion with continuous use,” Dr. Ntonis says. Also made with hyaluronic acid, arnica flower extract, and inulin, the formula improves the skin’s hydration levels and floods it with antioxidant protection. The treatment works best on under-eye lines and wrinkles, where it increases radiance while balancing moisture levels and improving skin texture.
- Key Ingredients: Peptides, hyaluronic acid, arnica
- Fragrance-Free: Yes
- Size: 1 ounce
Best Hydrating: Ourself HA+ Replenishing Serum
- Why We Love It: Daniel Gould, MD, PHD, a board-certified plastic surgeon in Beverly Hills, recommends Ourself’s high-tech cream to patients wanting to allay the return of wrinkles between treatments. “This serum uses a proprietary delivery technology to transport hyaluronic acid molecules beneath the stratum corneum closer to the dermis where volume loss originates—this is exciting new technology!” he says. “Unlike traditional hyaluronic acid topicals, this formulation delivers clinically significant hydration and volume enhancement.” He adds that a study sponsored by the brand proved that 95% of users had smoother skin with decreased wrinkle depth after four weeks, with imaging to back up the claims. “This is the closest topical alternative to filler in terms of temporary plumping—and it’s also phenomenal on the lips,” Gould says.
- Key Ingredients: Hyaluronic acid, firming intides, subtopical firming technology
- Fragrance-Free: Yes
- Size: 15 milliliters / 0.5 ounces
Best Hyaluronic Acid Serum: Alastin Skincare HA Immerse Serum
- Why We Love It: Another high-tech salve for plumping and hydration, Alastin Skincare’s HA Immerse Serum is a top pick for Dr. Gould. “Alastin’s patented Octapeptide-45 technology supports natural hyaluronic acid production within the skin, providing both immediate plumping and long-term skin density benefits,” he says. He notes that a 2021 in vitro study on the product demonstrated its capacity to increase hyaluronic acid synthesis and improve dermal matrix organization to reduce the appearance of fine lines. “We use this product post-laser and after injectables to reinforce skin hydration and barrier integrity,” he says. “It helps prolong clinical results."
- Key Ingredients: Octapeptide-45, hexapeptide-11, silver mushroom (tremella)
- Fragrance-Free: Yes
- Size: 1 ounce
Best With Retinol: ProX by Olay Dermatological Anti-Aging Deep Wrinkle Treatment
- Why We Love It: Dr. Mark praises ProX by Olay’s formula for its combination of collagen-boosting ingredients. “It contains retinol, peptides, and vitamin B3,” he explains. “The amino acids of peptides signal an ‘SOS’ response to the skin as it recognizes fragments of collagen, prompting the skin to react by stimulating [new] collagen.” He adds that vitamin B3 is a known anti-inflammatory that refines the pores and smoothes skin’s texture, while retinol is a key ingredient for any wrinkle-filler as it’s been “scientifically proven to help with virtually all signs of aging.”
- Key Ingredients: Pro-retinol, niacinamide, amino peptides
- Fragrance-Free: No
- Size: 1 ounce
Best Mask: La Prairie Platinum Rare Haute-Rejuvenation Mask
- Why We Love It: For a needle-free solution that delivers fresh-from-the-clinic results—or, as close to them as a topical can achieve—look no further than La Prairie’s ultra-luxe, dual-phase mask. The product comes with 12 vials of potent serum and cream that, as the price tag indicates, aren’t made with run-of-the-mill ingredients. “Platinum Rare Haute-Rejuvenation Mask offers the opportunity to ‘short-circuit the lengthy process of extracellular matrix regeneration, thanks to the revolutionary Macro-Infusion Technology in the concentrate,” the brand’s director of innovation, Daniel Stangl, tells Vogue. “This allows a fast and needle-free delivery of large molecules of hyaluronic acid and collagen. As a result, the skin is instantly plumped, smoothed, and refined, and its moisture is increased.” Dr. Stangl explains that the high-potency concentrate is just the first phase of the high-tech treatment. “The second phase, the ultra-sensorial cream, reactivates key rejuvenating processes to stimulate the formation of new hyaluronic acid, collagen, and ceramides in the skin in a sustained way,” he says. “This dual-phase strategy makes the [mask] the ideal complementing partner for filling procedures to work during the time between filling appointments.”
- Key Ingredients: Macro-Infusion Technology, hyaluronic acid, collagen, Platinum Multi-Peptide, cellular complex
- Fragrance-Free: No
- Size: 12 vials at 0.02 ounces each plus one 0.67 ounce cream
Everything You Need to Know
Do wrinkle fillers really work?
“Topical wrinkle products can be highly effective adjuncts [to professional treatments]—particularly those that support hydration, collagen remodeling, and extracellular matrix regeneration,” Dr. Gould says. “Topical wrinkle fillers don’t paralyze muscle or physically restore volume like injectables do, but they do improve skin elasticity, reduce superficial lines, and preserve a youthful appearance when used consistently.”
Which wrinkle filler is best?
Below, Dr. Ntonis breaks down the types of products that can best step in to fill wrinkles between injectable appointments.
- Hyaluronic Acid Serums: “These serums are a hydration powerhouse, capable of drawing moisture into the skin’s surface to immediately reduce the appearance of fine lines by plumping up the skin,” he says. “Their deeply moisturizing effect can leave the skin looking smoother, fuller, and more youthful.”
- Retinol Creams: “By promoting cell turnover and stimulating collagen production, retinol creams work to gradually diminish the depth of wrinkles over time,” Dr. Ntonis notes. “They are key for anyone looking to improve skin texture and reduce the visible signs of aging.”
- Peptide Complexes: “With their ability to assist in skin repair and boost collagen production, peptide complexes can firm the skin and smooth out wrinkles,” Dr. Ntonis notes. “These are particularly effective for targeting specific areas of concern and improving overall skin resilience.”
- Vitamin C Serums: Though Vitamin C serums are best known for their brightening properties, Dr. Ntonis notes that they also play a crucial role in promoting collagen synthesis. “Vitamin C serums aid in improving skin elasticity and firmness, contributing to a more youthful and radiant complexion,” he says.
- Niacinamide (Vitamin B3) Products: Ntonis praises niacinamide as a versatile ingredient that strengthens the skin’s barrier, reduces redness and blotchiness, and smoothens fine lines and wrinkles. “By improving skin elasticity and boosting the skin s barrier function, niacinamide helps to maintain skin hydration and smoothness,” he says. “Its anti-inflammatory properties make it suitable for all skin types, including sensitive skin, and it enhances skin texture and tone with consistent use.”
What ingredients should you look for in a wrinkle filler?
According to Dr. Gould, the ingredients below represent the gold standards for plumping and smoothing wrinkles between appointments:
- Hyaluronic acid (HA): for volumizing hydration and plumping
- Exosomes or growth factors: for increased collagen production and accelerated skin repair
- Peptides: for firmness and extracellular-matrix support
- Niacinamide: to reduce inflammation and strengthen the skin barrier
- Ceramides and antioxidants: to preserve skin health and prevent further degradation
- Retinol (or over-the-counter retinoids): Dr. Khalifian adds that retinol and retinoids are crucial for boosting cellular turnover, fading fine lines over time, and improving skin texture
Can similar results to Botox and filler be achieved at home?
“No topical can replace the biomechanical action of neuromodulators or the structural volume provided by dermal fillers,” Dr. Gould says. “But topicals can significantly prolong results, minimize the appearance of dynamic and static wrinkles, and enhance overall skin health, especially when paired with in-office treatments and at-home devices like red-light therapy or microneedling.”
How long do wrinkle fillers last?
“Most topical wrinkle fillers work on the surface of the skin, so their effects are temporary, usually a few hours, maybe a full day if your skin is well hydrated and you’re layering them right,” Dr. Khalifian says. “But the beauty of them is that you see results almost immediately, which is exactly what some of my patients want before a big event or when their skin is feeling tired or dry.”
Meet the Experts
- Daniel Gould, MD, PHD, is a board-certified plastic surgeon in Beverly Hills.
- Saami Khalifian, MD, FAAD, is a board-certified dermatologist at SOM Aesthetics in Encinitas, California.
- Kenneth Mark, FAAD, FACMS, is a board-certified cosmetic dermatologist and injectables expert.
- Akis Ntonis is a board-certified aesthetic injector and the cofounder of Aion Aesthetics in New York.
- Daniel Stangl is the director of innovation at La Prairie.