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Let’s begin with the good news: Many forms of skin discoloration, like sun spots and brown patches, do eventually fade. But how long that takes is anyone’s guess, which is where the best serum for hyperpigmentation can make all the difference. These formulas contain ingredients that upend skin’s pigment-production process, helping to fade discoloration, even out skin tone, and restore a glow in a matter of weeks.
Vogue’s Favorite Serums for Hyperpigmentation:
Featured in this article
Many of these active ingredients work in complementary ways: Take vitamin C and niacinamide, which target the formation of melanin (the pigment in skin) in two different steps before it ever reaches the skin’s surface. Meanwhile, retinoids “are fantastic for accelerating skin turnover, helping to fade existing dark spots and prevent new ones from forming,” explains Hope Mitchell, MD, a board-certified dermatologist in Perrysburg, Ohio.
Because they work via different mechanisms in the skin, these ingredients are best used (and often found) in combination—the more, the merrier. Another advantage? The various ingredient lineups can also cater to the different sources of hyperpigmentation, whether you’re targeting post-acne hyperpigmentation or hormonally driven melasma. In other words, the best serums for hyperpigmentation are anything but one-size-fits-all. With that in mind, scroll ahead for dermatologists’s top picks.
In This Story:
- What causes hyperpigmentation?
- What are the different types of hyperpigmentation?
- What skin types are most prone to hyperpigmentation?
- Can pigmentation actually be removed with a serum?
- What ingredients can improve the look of pigmentation?
- What else can you do to prevent dark spots?
- Are serums for hyperpigmentation worth it?
- Why are serums so effective when it comes to tackling hyperpigmentation?
- How long does it take to treat hyperpigmentation?
- How can I treat hyperpigmentation?
- Meet the experts
Best Overall: Isdin Melaclear
- Why We Love It: “This serum contains vitamin C and phytic acid, which work together to brighten the skin and reduce dark spots,” says Danilo Del Campo, MD, a board-certified dermatologist based in Chicago. He notes that it works well for both post-inflammatory hyperpigmentation—which can arise after acne and sun exposure, which both stoke inflammation—as well as melasma. “I’ve seen consistent results with it,” he says.
- Key Ingredients: Vitamin C, phytic acid, green tea extract
- Size: 0.5 fl oz
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Potent enough to tackle stubborn melasma | May cause redness on sensitive skin |
Visible results within a few weeks |
Best for Melasma: SkinCeuticals Discoloration Defense
- Why We Love It: For her patients with melasma—a chronic condition fueled by hormones and sun exposure—New York City board-certified dermatologist Michelle Park, MD, recommends this formula in combination with a separate vitamin C serum. “It is a unique combination of niacinamide, kojic acid, and tranexamic acid that is gentle but incorporates many different pigmentation-fighting ingredients together,” she says.
- Key Ingredients: Niacinamide, kojic acid, tranexamic acid
- Size: 1 fl oz
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Addresses most types of hyperpigmentation | Can take a longer time to yield results |
Gentle enough for sensitive skin types |
Best Vitamin C: Medik8 C-Tetra Advanced
- Why We Love It: At first, the potent 20% concentration of tetrahexyldecyl ascorbate—a highly stable yet gentle form of vitamin C—seems like the highlight in this lightweight gel-serum. But the supporting ingredients do much of the heavy lifting here; phyto-exosomes deliver barrier-replenishing proteins and lipids, while acetyl zingerone, an antioxidant, enhances the effects of vitamin C. This combination lends the serum the ability not only to brighten hyperpigmentation, but to defend skin from the environmental aggressors that often cause it.
- Key Ingredients: Vitamin C, acetyl zingerone, hyaluronic acid, phyto exosomes
- Size: 30 ml
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Has a pleasant citrus scent | Contains essential oils that could potentially be irritating |
Absorbs seamlessly and layers well beneath moisturizer |
Best for Age Spots: SkinMedica Even and Correct Advanced Brightening Treatment
- Why We Love It: While SkinMedica is known for its growth factors, this serum is proof of its expertise in brightening agents too. The formula comprises 9% of a blend of niacinamide, tranexamic acid, and lotus sprout extract, which work in tandem to fade a variety of hyperpigmentation—melasma among them, according to the brand. Grape extract, meanwhile, supplies moisture and softens the look of fine lines and wrinkles, making this a worthwhile option for those experiencing discoloration as a result of aging.
- Key Ingredients: Lotus sprout extract, niacinamide, tranexamic acid
- Size: 2 fl oz
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Clinically proven to treat melasma | Can feel tacky until it dries down |
Address other signs of aging, like wrinkles |
Best Drugstore: La Roche-Posay Mela B3 Dark Spot Serum With Melasyl + Niacinamide
- Why We Love It: This hardworking serum “works wonders for brightening skin and reducing the appearance of dark spots,” Dr. Mitchell says. The end result of nearly two decades of research, a new compound called Melasyl bonds to a precursor of excess melanin, effectively taking this hypothetical pigment out of commission and therefore fading existing and preventing new discoloration. It works alongside 10% niacinamide for a comprehensive approach, giving it quite a lot bang for your proverbial buck. Plus, “the inclusion of additional antioxidants ensures protection from further skin damage that could worsen pigmentation,” Dr. Mitchell says.
- Key Ingredients: Melasyl, niacinamide
- Size: 1 fl oz
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Won’t inadvertently lighten deeper skin tones | Can take months to fade existing dark spots |
Gentle enough for reactive skin types |
Best for Acne Scars: Topicals Faded Brightening and Clearing Serum
- Why We Love It: Although you can use this all over, this thin, gel-like serum—which went viral for its sheer efficacy—is designed to offer a targeted treatment, making it ideal for acne scarring and errant dark spots alike. Also worth noting: The formula, which is powered by a blend of azelaic acid, niacinamide, and tranexamic acid, is technically fragrance-free, but it does have a strong scent—although a recent reformulation has improved it.
- Key Ingredients: Azelaic acid, niacinamide, tranexamic acid
- Size: 1.7 fl oz
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Also helps to address active acne via azelaic acid | The tube can make it hard to dispense |
Can tackle acne scars as well as post-inflammatory hyperpigmentation |
Best Preventative: Clinique Even Better Clinical Radical Dark Spot Corrector + Interrupter Serum
- Why We Love It: The best way to manage hyperpigmentation is to prevent it from forming in the first place. That’s the gambit behind this serum, which contains both vitamin C and the brand’s patented CL302 Brightening Complex; it includes antioxidants, salicylic acid, and a yeast extract that busts up large clumps of pigment, among other ingredients. To stymie future spots, a blend of green tea and rice bran extracts quell the inflammation that so often leads to hyperpigmentation.
- Key Ingredients: Salicylic acid, vitamin C, yeast extract
- Size: 1 fl oz
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Gently resurfaces skin for immediate brightening | Might be too powerful for sensitive skin types |
Has a dense texture, but absorbs quickly into skin |
Best K-Beauty: Beauty of Joseon Glow Deep Serum
- Why We Love It: Serums intended to treat hyperpigmentation aren’t typically known for their hydrating properties, which is where this particular formula departs. Rather than your standard water base, nearly two thirds of the serum consists of rice bran water, an amino acid-rich fluid that has inherent moisturizing properties. Alongside this is 2% alpha-arbutin, which dials down enzyme activity critical for melanin production. Better yet, the lightweight texture sinks quickly into skin and without a tacky feel.
- Key Ingredients: Rice bran water, alpha-arbutin, niacinamide
- Size: 1 fl oz
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Works quickly to deliver glass-like radiance | Nothing to note |
Doubles as a hydrating serum |
Best for Mature Skin: 111Skin Repair Serum NAC Y²
- Why We Love It: This clever formula sets out to enhance your skin’s own production of glutathione, a do-it-all antioxidant that can boost skin elasticity, repair skin cells, and interfere with pigment production, thereby brightening skin. Rather than simply supplying the active, though, it deploys the proprietary NAC Y2 complex. This pairs vitamin C; escin; and N-acetylcysteine (the titular NAC), designed to encourage its synthesis, offering lasting results over time.
- Key Ingredients: Vitamin C, escin, N-acetylcysteine
- Size: 1 fl oz
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Actively moisturizes skin and supports the barrier | Some don’t love the scent, though it contains fragrance |
Can address both brown and purple spots, as well as redness |
Best Post-Procedure: Allies of Skin Tranexamic and Arbutin Advanced Brightening Serum
- Why We Love It: If you’re doing a series of chemical peels or laser resurfacing to lighten pigmentation—thus compromising skin—a retinoid or vitamin C may be too irritating. That’s the beauty of this gentle but no less potent serum, which pairs 3% tranexamic acid and 2% alpha arbutin with other brightening agents, like licorice root extract. It’s free of potentially harsh exfoliants, instead offering peptides to actively nourish and strengthen vulnerable skin.
- Key Ingredients: Alpha arbutin, tranexamic acid, licorice root extract
- Size: 1 fl oz
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Tackles dark spots as well as redness | The lower concentrations of actives means you may have to wait to see results |
Sinks in quickly and won’t pill |
Best Overnight: Epi.logic Double Feature AHA Overnight Facial
- Why We Love It: The brainchild of board-certified oculofacial plastic surgeon Dr. Chaneve Jeanniton, this potent formula is among the best retinol serums, full stop. It pairs a time-released blend of retinol and retinoid with lactic and mandelic acids to make quick work of dead skin cells—revealing the fresh skin (ostensibly with less excess melanin) beneath. Lest that sound harsh, the actives are housed in a base of squalane, which helps skin maintain moisture.
- Key Ingredients: Retinol, lactic acid, mandelic acid
- Size: 1 fl oz
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Has a nourishing, almost creamy lotion-like texture | May require an acclimation period if you’re new to retinol |
Pairs typical brighteners with retinoids |
Best Budget: The Ordinary Alpha Arbutin 2% + HA
- Why We Love It: Across its portfolio of products, The Ordinary skips the typical filler ingredients and instead emphasizes the results-driven actives. That’s no exception in this formula, which spotlights alpha-arbutin. It’s “a gentle ingredient that inhibits melanin production, reducing hyperpigmentation and dark spots,” Dr. Mitchell says. Meanwhile, the addition of hyaluronic acid lends skin extra hydration and bounce. The combination makes for a serum so easygoing that even those with reactive skin can use it.
- Key Ingredients: Alpha-arbutin, hyaluronic acid
- Size: 30 ml or 60 ml
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Works as a hydrating serum | Has a slightly sticky feel |
Gentle enough for sensitive skin types |
Best for Uneven Tone: Omorovicza Even Tone Serum
- Why We Love It: Intended to deliver brightening where it’s most needed, this thoughtful serum pairs niacinamide and a few ultra-gentle exfoliating acids—mandelic and gluconic acids, both mild enough for daytime use—with amber microalgae. This modulates melanin formation, intuitively targeting areas with an overproduction in order to maintain an all-around even tone.
- Key Ingredients: Niacinamide, mandelic acid, amber microalgae
- Size: 0.17 fl oz, 1 fl oz
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Has a nice herbal scent (although it contains fragrance) | Sensitive types may want to use it sparingly |
Doesn’t pill beneath other products |
Best for Sensitive Skin: SkinBetter Science Even Tone Correcting Serum
- Why We Love It: Instead of the usual suspects, this serum is packed with licorice extract and alpha arbutin, which are two plant-derived antioxidants. As a result, it can “target hyperpigmentation without causing irritation,” Dr. Del Campo says. “I love it because it’s gentle enough for daily use, even on sensitive skin.” What levels up its efficacy, too, is diglucosyl gallic acid, an antioxidant that works in multiple ways to prevent excess melanin production.
- Key Ingredients: Licorice extract, diglucosyl gallic acid, alpha arbutin
- Size: 1.7 fl oz
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Helps with overall skin tone, as well as specific spots and patches | May take months to see results |
Pairs two gentle brightening agents, so mild enough for even very sensitive skin |
Everything You Need to Know
What causes hyperpigmentation?
First, a brief primer: “Hyperpigmentation occurs when excess melanin, the pigment responsible for skin color, is produced in certain areas of the skin,” Dr. Del Campo says. Depending on your skin tone, this melanin can appear as spots, patches, or just generally uneven skin tone.
As for the causes, these can vary—but inflammation plays a big role in sending production into overdrive, which is why the aptly named post-inflammatory hyperpigmentation is the most common form, according to Dr. Park. “Any type of traumatic or inflammatory event to the skin, including acne, has the potential to increase activity of the melanocytes, which are pigment-producing cells,” she says. That can cause pigment to “spill” out into the upper layers of skin.
Dija Ayodele, an aesthetician and author of Black Skin, explains that several things can cause hyperpigmentation:
- Sun exposure: The sun is a major contributor. UV rays stimulate melanin production, leading to darker patches in areas where the skin is overexposed.
- Inflammation: Skin conditions such as acne, spots, or blackheads, particularly when picked at, can trigger inflammation that leads to hyperpigmentation. Eczema and other inflammatory skin conditions can also cause discoloration.
- Mechanical damage: Repeated actions like shaving, tweezing, threading, or waxing can injure the skin, which in turn leads to dark spots or patches.
- Allergies: Allergic reactions, especially those that involve constant rubbing of the skin around the eyes or nose, can inflame the skin. This is especially pronounced on Black skin due to more active melanin cells.
- Injuries and wounds: Cuts, scrapes, and general wounds can leave behind hyperpigmented areas as the skin heals.
- Hormonal changes: Menopause, along with other hormonal fluctuations, can affect skin quality, potentially increasing patchiness and hyperpigmentation.
Essentially, any source of inflammation or irritation, combined with the body’s natural response through melanin production, can lead to hyperpigmentation.
What are the different types of hyperpigmentation?
Post-inflammatory hyperpigmentation often contributes to the dark spots that arise after a breakout or acne scarring when you’re dealing with a stain on skin versus a textural concern (like an indentation in skin). They can fade on their own over time, but the process may take weeks to months, Dr. Park says. Meanwhile, “lentigos, or sunspots, are seen in photodamaged skin and due to an increase in melanocyte activity caused by UV exposure,” she says.
Yet another form of hyperpigmentation is melasma, which is frequently seen among pregnant people (although anyone can develop it). “It is a benign condition that causes hyperpigmentation most commonly presenting above the lip in the mustache area, cheeks, and forehead,” Dr. Park says. Hormones and UV exposure can both play a role, contributing to an uptick in melanin production that ultimately leads to a brown-toned discoloration. It can become chronic, too, meaning that a thoughtful approach with the help of a dermatologist is usually recommended for this.
What skin types are most prone to hyperpigmentation?
People with darker skin tend to be especially vulnerable to hyperpigmentation “due to having more active melanocytes,” Dr. Danilo says. That means that any skin trauma, inflammation, or hormonal changes can result in more noticeable dark spots—which is why post-inflammatory hyperpigmentation tends to be a bigger problem among this demographic than it is among people with fair skin. (In fact, research has found it to be the earliest sign of aging among people of color, whereas white folks are more prone to wrinkles.)
Can pigmentation actually be removed with a serum?
It depends on the pigmentation in question. “Over-the-counter face serums can be effective, especially for milder cases of post-inflammatory hyperpigmentation,” Dr. Danilo says; these include acne scars or minor skin wounds. That’s because the melanin is in the epidermis, or most superficial, layer of skin.
On the other hand, “pigmentation disorders caused by deposition of melanin in deeper layers of the skin, which is more rarely seen, will not respond to these types of topical treatments and should be evaluated by a board-certified dermatologist,” Dr. Park says. “For a condition like melasma, which is environmentally dependent, it is a chronic struggle that will unfortunately worsen at times.”
Also, if you experience recurrent hyperpigmentation stemming from a repeat cause—for instance, acne continuously pops up, creating new dark spots—then a visit to the dermatologist is recommended so you can address the underlying issue (in this case, the acne).
Finally, keep in mind that addressing hyperpigmentation is a commitment. “Any treatment used for dyspigmentation will realistically take weeks to months and require consistent use,” Dr. Park says. “Results are not immediate but gradual.” And on that note, to both see and maintain results, using a broad-spectrum sunscreen with SPF 30 or higher is critical. “Without consistent sun protection, it’s very hard to see significant improvements, as UV exposure can quickly undo the progress made by serums,” Dr. Del Campo says.
What ingredients can improve the look of pigmentation?
One advantage of hyperpigmentation is that, when it comes to active ingredients, the world is your oyster. There are a bevy of actives that can help, some of which are recognizable even to skin-care newcomers. Vitamin C, for instance, is “a powerful antioxidant that brightens and inhibits melanin production,” Dr. Del Campo says. (Dr. Park, for her part, thinks that it should be a staple in any good skin-care regimen, hyperpigmentation notwithstanding.)
Niacinamide is another ingredient that’s earned recent buzz; it works through a different mechanism than vitamin C to stymie pigment production, which is why you can frequently find them paired together. It “helps reduce the appearance of dark spots and strengthens the skin barrier, making it especially useful for sensitive skin types,” Dr. Del Campo says. Azelaic acid is another ingredient he recommends, especially for post-inflammatory hyperpigmentation and melasma. “It works by inhibiting an enzyme involved in melanin production,” he says. You’ll also see kojic acid, tranexamic acid, and licorice extract among these formulas.
Finally, anything that helps skin shed its upper layer—which may house melanin deposits—can also fade the look of hyperpigmentation. That includes alpha hydroxy acids, such as glycolic acids, and retinoids. “These promote skin cell turnover, which helps fade dark spots over time,” Dr. Del Campo says.
What else can you do to prevent dark spots?
Besides using a hyperpigmentation serum after the fact—and being proactive about your sun protection—early intervention can make a world of difference. It can be difficult to completely prevent hyperpigmentation, Dr. Mitchell says, but incorporating gentle exfoliation and antioxidants (via a vitamin C serum) in your skin-care routine can keep it from getting worse.
It can also help to identify (and address) the source of your hyperpigmentation, which is part of the reason wearing sunscreen is so important. UV rays not only worsen discoloration, but they can also “trigger melanin production,” Dr. Mitchell says. And if your dark spots are the result of an inflammatory event in your skin—like, for instance, a breakout—then being proactive about your acne treatment can effectively remove the root cause.
Are serums for hyperpigmentation worth it?
If you’re strategic about the ingredients in your serum and diligent about using it, then, yes, serums for hyperpigmentation are worth it to fade dark spots or discoloration. “Preventing hyperpigmentation comes down to proactive sun protection and early intervention,” Dr. Mitchell says. And a consistent routine—inclusive of a serum for hyperpigmentation—is a key part of the latter.
However, keep in mind that the type of hyperpigmentation you’re targeting can matter. For sun spots and acne marks, “ingredients like vitamin C and niacinamide can be quite helpful in fading dark spots over time,” Dr. Del Campo says. But for melasma, which is one of the more stubborn forms of hyperpigmentation, an over-the-counter serum might not be strong enough to deliver results, he says. In that case, “prescription treatments or procedures may be needed,” he says.
Why are serums so effective when it comes to tackling hyperpigmentation?
“Serums have a very fine and lightweight texture, so they are able to penetrate the skin,” Ayodele explains, while Dr. Vanita Rattan, cosmetic formulator and CEO of Skincare by DrV, adds a caveat: “Serums with a higher fat content tend to absorb better into the skin compared to silicone-based gels and watery serums.” Then, of course, it’s all down to the ingredients. “You want a mixture of things that all work in slightly different ways on pigmentation,” Ayodele shares. She recommends hexylresorcinol, alpha arbutin, kojic acid, hydroquinone (on prescription only), niacinamide, vitamin C, retinoid, and liquorice extract. Tranexamic acid, which is similar to glutathione, is also great to use, while “glycolic, lactic, and azelaic acid all help to smooth and refine skin texture, getting rid of old skin cells that can hang on to stale pigment on the surface of the epidermis.”
How long does it take to treat hyperpigmentation?
“It depends on how stubborn the pigmentation is, how long it’s been there for, and whether the triggers are ongoing,” Dr. Vanita says. “For example, if you have melasma and you’re not protecting your skin from UV radiation by using a broad-spectrum SPF, it’s just going to get worse and worse, especially in the summertime.” That said, she continues, it’s easier to treat new instances of hyperpigmentation, such as dark spots that crop up after pimples or mosquito bites, right away. “If the hyperpigmentation has been there for a long time, as in the case of melasma or dark circles, it’s much harder to treat. This can take six to nine cell cycles, meaning six to nine months, before you see results.”
How can I treat hyperpigmentation?
Preventing and managing hyperpigmentation involves a combination of daily skin-care practices and occasional professional treatments. Although hyperpigmentation is a natural skin process, the following steps can help prevent it and fade existing dark spots:
- Tailor your skin-care routine: A skin-care routine tailored to your skin type can help maintain the integrity of your skin barrier, which can minimize the irritation and inflammation that often leads to hyperpigmentation and dark spots.
- Use pigment-inhibiting ingredients: Incorporating ingredients such as vitamin C, niacinamide, azelaic acid, or hydroquinone into your skin-care routine can help regulate melanin production and prevent dark spots from forming or worsening.
- Apply SPF every single day: Regular use of sunscreen with an SPF of 30 or higher is essential in preventing hyperpigmentation. UV exposure can worsen dark spots and slow the fading process, so protecting your skin from the sun is crucial.
- Get professional treatments: Chemical peels exfoliate the top layers of the skin, encouraging the production of new skin cells and helping to fade hyperpigmentation, while microneedling can stimulate skin healing and promote collagen production, which can improve the appearance of dark spots.
Meet the Experts
- Dr. Danilo Del Campo, MD, is a board-certified dermatologist at Chicago Skin Clinic in Chicago.
- Dr. Hope Mitchell, MD, is a board-certified dermatologist in Perrysburg, Ohio.
- Dr. Michelle Park, MD, is a board-certified dermatologist at Washington Square Dermatology in New York.