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Last Looks | Mandy Moore

Produced by Vogue with Eli Lilly and Company | Ahead of attending Vogue World Hollywood with Lilly—a leading company in the fight against Alzheimer’s disease—Mandy Moore takes us behind the scenes of her getting-ready process. From hair and makeup to putting on a dress that feels like second skin, Moore reminisces about her own Hollywood career, underscoring the fulfilling and challenging role of Alzheimer’s patient Rebecca Pearson on This Is Us. #LillyPartner

Released on 11/21/2025

Transcript

I would describe my look as comfortable holiday ornament.

[upbeat music]

So I am in Los Angeles getting ready to go

to Vogue World Hollywood with Lilly, and I m really excited.

I m so excited to sort of see what Vogue

has in store for all of us.

I don t wanna do anything

that feels like too out of the box.

I wanna feel like just a polished,

elevated version of myself.

We re keeping the makeup really clean, and simple,

and natural, and letting sort of glowy skin show through.

And the same with hair, so it feels glossy,

and sort of fluffy a little bit,

because the dress is bold, you know, it s red sequin.

Like, I really want the dress

to do the talking.

Vogue World Hollywood tonight

is essentially celebrating Hollywood

in all its different iterations and forms.

I feel so grateful to have taken on so many different kinds

of roles, but I think if I really distill it down

to the one role that s been most meaningful in my life,

it s without a doubt Rebecca Pearson from This Is Us.

I think the experience of portraying Rebecca

and doing the deep dive into all of the research

around Alzheimer s, it made me a passionate advocate.

So to be able to partner with Eli Lilly

and Company who has been working in the Alzheimer s space

for decades and is so passionate

about the work they re doing

around early detection and diagnosis,

and just the conversation in general.

I think it s so important

that we all work together collectively

to de-stigmatize this idea around diagnosis

and what that means.

I felt like it was all the more important

to be as responsible as possible to do all of the research.

I immersed myself in everything

I could get my hands on, speaking to patients

who had been diagnosed with Alzheimer s.

And I think there are early signs of Alzheimer s

that people often just write off

as normal symptoms of aging.

You know, forgetting faces and facts.

But when it comes to brain health

and cognitive health,

just prioritizing it in the same way you would

with anything else,

and going and talking to your doctor

about it is, is the best bet.

I m gonna go get changed.

Mandy is an incredible muse.

She looks great, you know, it s fun to play dress up

with her, and she really brings the clothes to life.

She is wearing this beautiful tomato red sequin slip dress

that just felt very effortless, very her,

kind of like a second skin.

Fun, still fashiony,

but you and I can have a good time.

My mom s mom had Alzheimer s,

and we were actually very close,

and she was one of the first people

that introduced me to fashion.

I used to raid her closet

and dress up in all of her fun things with flair.

My grandmother also, you know,

loved the color red and so do I.

And so this dress in particular feels like both of us,

where it s the color, it s the shine,

but it s also a bit of the 90s homage.

[upbeat music]

So this is the final look.

I think what s particularly special about this dress

for me is it was made by the same folks

who made my wedding dress.

So I feel that sort of connection.

They re Angelinos like me,

and I just like, it s comfortable, it s sexy, it s wearable,

it s all the things you sort of want to feel at an event.

I think it s important to sort of keep

in mind before going to an event

or an experience like this, to be present,

to appreciate these little threads, these little moments

that sort of comprise of your story and your life.

Thank you so much for hanging out

and getting ready with me Vogue,

but I gotta go make some new memories.

[uplifting music]